Sytropin Vs. GenF20 Plus

Box of GenF20 Plus next to a bottle of Sytropin

Human growth hormone (HGH) is an essential hormone produced in the pituitary gland that plays a crucial role in multiple bodily functions. As we age, HGH production begins to decline, resulting in various undesirable effects like decreased muscle mass, bone density loss, increased body fat, lackluster skin, and reduced energy levels.

Thankfully, HGH releasers provide a safe and natural way to stimulate your pituitary gland to produce more growth hormone. Two popular oral spray HGH supplements are Sytropin and GenF20 Plus. But what exactly are these products, and how do they work? Which one offers superior results?

Sytropin ( entered the HGH arena in 2012 as an oral spray designed to boost lagging growth hormone levels. It contains a proprietary blend of amino acids, botanical extracts, and other nutrients clinically shown to increase HGH production.

GenF20 Plus (¬†debuted in 2004 as one of the first HGH releaser pills and later unveiled its spray formula. It also harnesses ingredients like amino acids to fire up your body’s HGH.

In this comparison guide, we’ll analyze the ingredient profiles, customer reviews, safety, and overall value of Sytropin vs GenF20 Plus sprays. By the end, you’ll have the knowledge to determine which oral HGH spray is the better choice for your anti-aging, bodybuilding, and wellness needs.

Key Highlights of Sytropin and GenF20 Plus


Sytropin spray bottle
  • Increases lean muscle mass.
  • Decreases body fat.
  • Improves recovery time.
  • Boosts energy and performance.
  • Enhances the immune system.

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GenF20 Plus

GenF20 Plus
  • Increases in lean muscle mass & weight loss.
  • Noticeable increases in energy & sex drive.
  • Improves memory & focus.
  • Enhances bone and joint health.

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How Sytropin and GenF20 Plus Work

To understand how Sytropin and GenF20 Plus boost growth hormone levels, you first need to know how HGH is produced naturally. The pituitary gland contains special cells called somatotrophs that release HGH into the bloodstream. HGH production is regulated by a complex neuroendocrine feedback loop involving two hormones produced in the hypothalamus – growth hormone releasing hormone (GHRH) and somatostatin (SS).

Sytropin and GenF20 Plus work by supplying key amino acids that stimulate the pituitary gland and hypothalamus. For example, L-arginine and L-lysine have been clinically shown to increase GHRH output from the hypothalamus. This ramps up signaling to the pituitary to produce and discharge more HGH. Other amino acids like glycine provide the raw materials to manufacture more growth hormone.

In addition to amino acids, both sprays contain botanical compounds that suppress somatostatin. Since SS inhibits HGH output, reducing its production allows for enhanced growth hormone release. Mucuna pruriens in GenF20 Plus and GABA in Sytropin curb somatostatin secretion. Lastly, the sprays include nutrients like vitamin B6, zinc, and chromium that are involved in the synthesis and activity of growth hormone.

By influencing hypothalamic hormones and providing HGH building blocks, Sytropin and GenF20 Plus can restart your body’s natural growth hormone production – increasing daytime and nighttime levels for whole-body benefits.

Comparing Key Ingredients

Let’s dig into the important active ingredients contained in Sytropin and GenF20 Plus sprays and analyze how they drive HGH release:

  • Amino Acids Both products contain amino acids like L-arginine, L-glutamine, and L-lysine that stimulate pituitary gland function. However, GenF20 Plus packs higher, clinically validated doses of these key amino acids.
  • Alpha GPC This choline precursor boosts HGH secretion and is found in GenF20 Plus but not Sytropin. Alpha GPC ensures sufficient levels of acetylcholine to enhance growth hormone stimulating signals.
  • GABA An inhibitory neurotransmitter, GABA inhibits somatostatin allowing greater HGH production. It’s included in Sytropin but not GenF20 Plus.
  • Deer Antler Velvet Contains collagen and IGF-1 to complement growth hormone’s anti-aging effects on skin and joints. Only in the GenF20 Plus formula.
  • Astragalus Root Extract Shown to increase HGH levels, this herbal extract gives Sytropin an advantage. Not found in the GenF20 Plus ingredients.

Based on the key active ingredients, GenF20 Plus appears to offer higher clinical doses of amino acids, while Sytropin provides unique botanicals like astragalus. But clinical evidence seems strongest so far for the amino acid approach of GenF20 Plus.

Product Reviews and Testimonials

Examining verified product reviews and user testimonials provides valuable real-world insights into how effective Sytropin and GenF20 Plus are for boosting HGH and improving wellbeing:

Sytropin Reviews

  • Aggregated rating of 4 out of 5 stars based on reviews across social media, with users reporting muscle gain, deeper sleep, and fat loss.
  • Mixed reviews on third-party sites. Some report excellent results, while others didn’t notice benefits.
  • No major clinical trials have been conducted on Sytropin itself.

GenF20 Plus Reviews

  • Aggregated rating of 4.5 out 5 stars based on 1300+ social media reviews across, with users reporting notable effects on metabolism, physical stamina, and immunity.
  • Consistently positive testimonials across websites like TrustPilot. Users cite anti-aging effects and muscle gain.
  • Clinical studies on GenF20 Plus ingredients show increased HGH, fat loss, and lean muscle mass.

Both products come with a money back guarantee if users aren’t satisfied. But GenF20 Plus seems to have more consistently positive reviews and clinical data supporting its formulation. Keep in mind results can vary based on the individual.

Cost and Value Comparison

When evaluating the value of Sytropin and GenF20 Plus, you need to look at the price per serving, discounts available, and overall efficacy based on ingredients:


  • Sytropin costs $59.95 per bottle for a 1-month supply. Each bottle contains about 120 sprays.
  • GenF20 Plus is $99.98 per month’s supply. One bottle contains 120 capsules plus 60 oral spray servings.


  • GenF20 Plus provides free shipping and volume discounts for 3 to 6 month supplies.
  • Sytropin offers significantly larger volume discounts on 3- and 6-month supplies.


  • As discussed earlier, GenF20 Plus has more clinical evidence and positive reviews backing its formulation.
  • This suggests GenF20 Plus offers superior value and results for the higher price tag.

GenF20 Plus seems to provide better value for money overall based on verified reviews, clinical data, and more potent ingredients despite the higher cost per bottle. But those on a tight budget may still benefit from Sytropin.

Pros and Cons

Sytropin spray bottle

Sytropin Pros

  • Contains amino acids clinically shown to increase HGH
  • Herbal extracts like Astragalus may support HGH release
  • Positive reviews for improved sleep, skin, lean muscle
  • Lower cost per bottle compared to GenF20 Plus
  • 67-day money back guarantee

Sytropin Cons

  • Mixed reviews on efficacy from some users
  • Fewer proven ingredients than GenF20 Plus
  • Lacks extensive clinical trials on the full formula
  • Lower doses of key amino acids than GenF20 Plus

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GenF20 Plus

GenF20 Plus Pros

  • High doses of amino acids to stimulate HGH
  • Additional ingredients like Alpha GPC boost results
  • Consistently positive customer reviews and testimonials
  • Clinical studies validate effectiveness and safety
  • 67-day refund policy provides consumer protection

GenF20 Plus Cons

  • Higher price per bottle than Sytropin
  • Requires taking both spray and pills for full effect
  • Results take 2-3 weeks to become noticeable
  • Slightly more reports of mild side effects

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Conclusion and Recommendation

In reviewing the key factors surrounding Sytropin and GenF20 Plus, GenF20 Plus appears to come out on top as the premier HGH releaser spray.

While both products contain proven HGH boosting amino acids, GenF20 Plus includes them at optimal clinical doses along with other ingredients like Alpha GPC to maximize HGH stimulation. The wider range of positive customer reviews and clinical evidence for GenF20 Plus also demonstrates its superior real-world results.

Sytropin does offer some unique herbal extracts not found in GenF20 Plus, and may provide a more affordable option. However, GenF20 Plus’s combination of potent ingredients, verified reviews, clinical data, and manufacturer reputation make it the better choice overall.

Keep in mind, individual results can vary based on factors like age, diet, and exercise regimen. But based on the analysis, we recommend GenF20 Plus as the #1 HGH releaser spray for boosting growth hormone levels, supporting anti-aging and fitness goals, and improving energy and wellbeing.

See Also: Our Full Sytropin Review and Full GenF20 Plus Review


Q: Are there any side effects from using Sytropin or GenF20 Plus?

A: These oral sprays use natural amino acids and herbal extracts to gently stimulate your own HGH production. When used as directed, side effects are rare. Some users report mild symptoms like nausea, bloating, or headache when first starting.

Q: How long until I see results from using an HGH releaser?

A: Most people notice some effects, like better sleep quality, increased energy, or fat loss, within 2-3 weeks. But the products recommend using for 2-3 months to experience full anti-aging, body composition, and wellness benefits.

Q: Do I need a prescription for these HGH supplements?

A: No, since Sytropin and GenF20 Plus encourage your pituitary gland to produce more of your body’s natural HGH, they are available over the counter without a prescription.

Q: What other lifestyle changes can help increase HGH levels?

A: Ensuring adequate sleep, managing stress, regular exercise, and nutritious low-glycemic meals all support healthy HGH secretion. Limiting alcohol and sugar intake also helps.

Q: Are there less expensive HGH-boosting alternatives?

A: Certain amino acid supplements like L-lysine, L-arginine, and glutamine can mildly boost HGH. But the synergistic formulas of Sytropin and GenF20 Plus will provide far superior results.

Q: Can Sytropin or Genf20 Plus Be Used by Individuals Under the Age of 18?

You should not use Sytropin or GenF20 Plus if you are under 18 years old. There are safety concerns and potential side effects associated with these products for individuals in this age group.

Q: Are There Any Known Drug Interactions With Sytropin or Genf20 Plus?

There are no known drug interactions with Sytropin or GenF20 Plus. However, it is always a good idea to consult with your healthcare provider to ensure that these supplements are safe for you to use.

Q: How Long Does It Typically Take to See Results From Using Sytropin or Genf20 Plus?

To maximize results with Sytropin or GenF20 Plus, it typically takes some time. Results vary, but many users start noticing improvements within a few weeks. However, it’s important to be aware of potential side effects.

Q: Are There Any Specific Dietary or Exercise Recommendations That Should Be Followed While Using Sytropin or Genf20 Plus?

While using Sytropin or GenF20 Plus, it is important to follow specific dietary and exercise recommendations. These recommendations can vary, so it is best to consult with a healthcare professional to determine what is suitable for you.

Q: Can Sytropin or Genf20 Plus Be Used in Conjunction With Other Supplements or Medications?

Yes, you can use Sytropin or GenF20 Plus in conjunction with other supplements or medications. However, it’s important to consider supplement compatibility and potential side effects. Always consult with a healthcare professional before combining any supplements or medications.

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