Ligandrol: LGD 4033 Benefits, Risks, Dosages & Cycles

Muscular man holding capsule of Ligandrol LGD 4033 with molecular graphic overlay.

Selective androgen-receptor modulators, or SARMs, have increased in popularity in recent years. Ligandrol (also called LGD-4033, Anabolicum, or VK5211) is one such SARM that you’ll frequently see mentioned. It’s a very effective substance, which is probably why it attracts more attention than other SARMs.

The following information is based upon the current clinical research and anecdotal user experiences. Continue reading to learn more about the drug and its side effects.

Note: This drug is not recommended for use as its safety and effects are not known. We present the most current information available from scientific and clinical literature to help readers understand the risks.

What is Ligandrol LGD 4033?

Ligandrol was originally developed to treat muscle wasting disorders. Many athletes and bodybuilders have begun using this drug due to its ability to build muscle tissue.

Ligandrol is classified as a selective androgen receptor modulator (SARM). The way that SARMs work is by selectively binding to androgen receptors. This results in enhanced performance with fewer side effects due to this special selective process.(1)

Keep in mind that LGD 4033 is an investigational drug. Since an accurate safety profile cannot be determined, we cannot recommend its use.

Ligandrol Benefits

Based on the available research and user reports, the greatest benefit of Ligandrol is its ability to rapidly increase muscle mass.(2) It has also been shown to increase bone mineral density, bone formation, and bone strength.(3)

Additionally, gains in strength, recovery, and a general performance enhancement are also reported. SARMs like Ligandrol are also being investigated for possible benefits to sexual function and mood.(4)

In short, this drug has so far been shown to potentially provide the following benefits:

  • Increases muscle mass
  • Improves bone health
  • Boosts strength and athletic performance
  • Enhances recovery
  • Elevates mood and sex drive

This effectiveness for bulking and increasing size is the primary reason why many people take it. It is sometimes also stacked with Andarine or RAD 140.

These effects typically begin to become noticeable within a week. While cycling Ligandrol, it is not uncommon for users to experience gains between 10-15 pounds.

However, PCT (post-cycle therapy) is necessary after the cycle ends in order to keep the majority of the gains made.

Ligandrol Risks and Side Effects

Ligandrol has not been proven to be safe and has not been approved for use in humans.

In human studies, the drug was well tolerated and showed significant dose-proportional gains in lean body mass and leg press strength. However, these studies used far lower doses, ranging from only 0.1 to 1 mg daily. The long-term side effects remain unknown.(5)

In one study, LGD-4033 administration was associated with suppression of total testosterone, SHBG, high density lipoprotein cholesterol, and triglyceride levels. Free testosterone levels and follicle-stimulating hormone showed significant suppression at only a 1 mg dose.(6)

Some side effects reported by Ligandrol users include:

  • Low testosterone
  • Headaches
  • Nausea
  • Water retention
  • Acne
  • Fatigue
  • Dry mouth

While these side effects are not life-threatening, the long-term effects of this compound are unknown and could be potentially dangerous. The most significant side effect of Ligandrol is its suppression of testosterone.

For those who do use it, you will need on-cycle support and post-cycle therapy. These supplements are essential for starting a cycle.

Ligandrol Dosage and Cycle

Clinical research and user reports have shown that LGD 4033 is a powerful SARM. A large dosage is not required to experience its performance-enhancing effects.

In fact, it has been proven to be effective even at doses as low as 1mg per day. Nevertheless, most users tend to take larger doses,

The typical dose of Ligandrol is 5-10mg daily. Most people do not exceed 10mg. According to many users, exceeding 10mg per day can lead to a higher rate of testosterone suppression or other adverse effects.

Ligandrol’s half-life is approximately 24-36 hours. This means that it’s only necessary to take it once per day. The majority of users take it in the morning with breakfast.

The average cycle lasts 6-8 weeks depending upon the goals of the user. Because Ligandrol can cause hormonal suppression, a post-cycle therapy is necessary following the cycle.

After completing their cycle, most users take Test Stack No.17 for a period of four weeks. This is necessary to boost testosterone and reduce estrogen in order to maintain size, strength, and sex drive.

Does Using LGD 4033 Require Post-Cycle Therapy?

Once ingested, SARMs such as Ligandrol suppress the body’s natural testosterone levels. PCT (Post Cycle Therapy), is therefore necessary.

Without PCT, it could take months for your hormones to return to normal levels. During this time you will experience low testosterone which can lead to you losing most of the gains you made.

Dim 3X is an excellent post-cycle therapy supplement for those taking SARMs.

You should begin taking it the day after the last dose of your cycle and continue for 4 to 6 weeks. Keeping two bottles on hand is a good idea in the event that you need to continue your PCT beyond the initial four weeks.

Dim 3X quickly starts to increase your testosterone levels while decreasing estrogen levels to bring your hormones back into balance. This will help you to keep your gains in muscle mass, strength, and performance. Additionally, you’ll prevent any negative effects on energy, mood, or sex drive.

This supplement can be purchased through the official PrimeGENIX website. The quality and effectiveness of this product make it well worth the price.

Be sure to prepare for your post-cycle therapy before you start a cycle with Ligandrol. If you neglect this important step, you will almost certainly wish you hadn’t.

For more information about Dim 3X, including current pricing, visit the PrimeGENIX website.

Is Cycle Support Necessary With Ligandrol?

Ligandrol has been linked to liver damage, therefore it’s important to use cycle support while taking Ligandrol.

It’s recommend that you obtain cycle support supplements that protect the health of your organs, including the liver and kidneys.

It is important to take support supplements during the whole cycle, from day one through completion. This includes supplements like TUDCA, milk thistle and Hawthorne berry, which are very effective in protecting against toxicity and organ damage.

LGD 4033 Alternatives

Many people are not comfortable taking an unapproved drug like Ligandrol, but there are two safe and legal-to-use alternatives called LIGABULK and LIGAN 4033. Both of these products were created to replicate Ligandrol without any of the risk, negative side effects, or legal ramifications.

However, these two alternatives will not decrease the natural production of testosterone, unlike Ligandrol. To the contrary, they each include active testosterone-boosting compounds that naturally increase the body’s own testosterone production, without any need for PCT.

In addition, their ingredients increase natural growth hormones in the body for substantial muscle gains. LIGABULK also provides anti-inflammatory effects to ease joint pain and speed up muscle recovery.

LIGAN 4033 and LIGABULK are both an excellent option for anyone who’s serious about increasing muscle size and strength, reducing joint pain and accelerating recovery – but safely, naturally, and legally.

See Also: The Complete Brutal Force Product Guide and the full CrazyBulk Product Review

Where to Buy Ligandrol

Because there is not enough clinical research on the safety of Ligandrol, we can’t recommend purchasing it. That said, you should only purchase it from a trusted source if you are certain about your decision to research it.

SwissChems is our preferred vendor for those who want to buy Ligandrol. They are the best choice because they maintain rigid quality control. Everything they sell is regularly third-party-tested for purity, and you can view the test results for yourself on their site.

In contrast, many online vendors do not perform testing or have inconsistent quality, and very often the ingredients used are ineffective or mislabeled. Although we can’t recommend the purchase of SARMs, SwissChems is the safest option for those who do.

Click here to buy Ligandrol from the SwissChems website.


Based upon the available limited evidence, Ligandrol appears to be an extremely effective SARM. However, We can’t recommend using SARMs because we still don’t know enough about them.

If you are looking to build muscle, we recommend LIGABULK. It hasn’t been associated with any side effects and we’ve seen dramatic results.

A single cycle of LIGABULK can help you gain up to 10 pounds. Get more information here.

Otherwise, you’ll need to buy a post-cycle therapy supplement (Test Stack 17) and cycle support supplements if you plan on taking LGD 4033.

These are vital to your health and gains, and you should not begin without them. For those looking to buy SARMs, SwissChems is a trusted source that we recommend.


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