PGH-1000 by Anabolic Research: Legal Growth Hormone & IGF-1 Releaser

Last Updated: September 21, 2025

Note: This article reflects personal use and research only and should not replace professional medical guidance. Speak with your doctor before considering PGH-1000 or any supplement. This article may contain affiliate links. If you purchase through these links, we may earn a commission at no additional cost to you. This helps support our content and ongoing testing efforts.

PGH-1000 Review Highlights

Rating:

My Results:

• It substantially increased lean muscle mass.
• I experienced noticeable fat loss.
• My energy & stamina levels were greatly improved.
• I noticed a boost in mood & motivation
• Healing & recovery were a breeze.

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Growth hormone and IGF-1 supplements can sometimes be a controversial topic because they are easily misunderstood and typically confused with substances like steroids. There is considerable debate about how effective they are, and it doesn’t help that many brands are, in fact, pure crap.

So, to set the record straight and lessen the confusion, I’ll go into the facts about these types of supplements, and specifically a product called PGH-1000.

Important: This review is based on personal use and research, and is not a substitute for professional medical advice. Talk to your doctor before trying PGH-1000 or any supplement.

What is PGH-1000?

PGH-1000 (Anabolics.com) is a powerful supplement manufactured by Anabolic Research. Formerly marketed as Pituitary Growth Hormone (pGH), PGH-1000 is offered as an effective way to increase IGF-1 levels, and is considered a best-kept-secret among bodybuilders and athletes alike.

For those who don’t know, IGF-1 is a direct precursor to human growth hormone, and when it increases, so does HGH. In fact, one of the best ways to measure human growth hormone is by getting a reading on IGF-1 levels.

By combining a proprietary blend of amino acids with pituitary gland extract, PGH-1000 is able to boost IGF-1 levels naturally in the body, producing a noticeable increase in body composition, muscle growth, and fat metabolism.

What Are the Benefits of PGH-1000?

Apart from the natural purposes of IGF-1, including how it makes sure adolescents grow normally, there are also countless other benefits and potential reasons why you’d want to add extra amounts of PGH-1000 to your body.

When IGF-1 levels are elevated in the body, nearly every system and function of the human body is enhanced. Some of the key benefits mediated by higher IGF-1 include:

• Increased Protein Synthesis: IGF-1 stimulates muscle protein synthesis, enabling faster muscle repair, growth, and gains in strength and power output.
• Enhanced Recovery: By reducing muscle damage and inflammation, IGF-1 helps muscles recover faster between intense bouts of exercise.
• Fat Loss and Metabolism: IGF-1 enhances the breakdown of stored fat for energy while also boosting resting metabolism.
• Brain Function: Higher IGF-1 is linked to improvements in focus, concentration, memory, learning, and other cognitive faculties.
• Anti-Aging Effects: Through better cellular health, tissue repair, skin quality, lipid profiles, and cardiovascular function, elevated IGF-1 can help combat age-related decline.
• Sexual Health: By supporting production of sex hormones and optimizing energy and blood vessel health, IGF-1 may improve sexual performance and satisfaction.
• Bone Mineral Density: IGF-1 increases calcium retention and the production of osteoblasts, strengthening bones.

With the greater ability to add on additional lean muscle mass, the benefits to bodybuilders and weightlifters is obvious. Some people might also use PGH-1000 in conjunction with other performance-enhancing supplements in order to improve athletic skills.

In addition, people have even  seen positive results in the appearance and quality of their skin by taking PGH-1000 as it seems to reduce signs of aging.

In essence, higher IGF-1 levels help maximize human performance, appearance, and general wellness in a myriad of ways. The compound impacts nearly every cell and system for whole body benefits.

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PGH-1000 Ingredients and What They Do

This product contains a proprietary blend of amino acids in specific measurements, combined with pituitary extract, to create a formula like no other.

Now, amino acids are readily available in all sorts of sports nutrition products, so there’s nothing unique about that. But something about this specific combination of aminos in these specific amounts is what makes this formula so special.

The ingredients for PGH-1000 includes:

• L-Glutamic Acid
• L-Proline
• L-Isoleucine
• L-Threonine
• L-Alanine
• L-Serine
• L-Phenylalanine
• L-Arginine
• L-Tyrosine
• L-Histidine
• L-Glycine
• L-Methionine
• L-Cystine
• L-Leucine
• Pituitary Substance
• HCIL-Valine
• Soy Protein

Here’s how the key components work:

L-Arginine

Arginine is known for its role in nitric oxide synthesis, which improves blood flow and nutrient delivery. It’s also studied for its potential to stimulate growth hormone release, especially when combined with exercise.(1)

Takeaway: May support GH secretion indirectly and enhance circulation for better pump and recovery.

L-Glutamic Acid, L-Alanine, L-Serine, L-Threonine, L-Proline

These are non-essential or conditionally essential amino acids that support:

• Protein synthesis
• Tissue repair
• Metabolism and neurotransmission

While not direct GH stimulators, they are important for muscle recovery and maintaining a positive nitrogen balance.(2)

Takeaway: Help optimize recovery conditions post-training, which may indirectly support muscle growth and hormonal balance.

L-Isoleucine, L-Leucine, L-Valine (BCAAs)

These are branched-chain amino acids, known for their role in:

• Muscle protein synthesis
• Reducing exercise-induced muscle damage
• Improving endurance and recovery(3)

Takeaway: Support muscle repair and performance, creating the ideal environment for GH to act effectively.

L-Tyrosine, L-Phenylalanine, L-Histidine

These amino acids play roles in neurotransmitter production (dopamine, norepinephrine, histamine), which influence mood, alertness, and hormonal signals.

L-Tyrosine has been shown to help with stress resilience during intense physical or mental exertion.(4)

Takeaway: May support neurological function and mental focus during workouts and recovery.

Pituitary Substance

This is a glandular extract believed to support endocrine health. While not widely studied in isolation, it’s often included in “pro-hormonal” or GH-supporting blends to mimic or influence pituitary activity — the gland responsible for GH secretion.

Note: This ingredient is controversial and lacks robust clinical evidence, but it’s used in some niche supplement formulas.

Takeaway: Intended to support pituitary function and possibly enhance natural hormone signaling, though research is limited.

Soy Protein

Soy is a complete protein source that provides all essential amino acids. It also contains arginine and glutamine, both relevant to muscle repair and immune health.(5)

Takeaway: Helps provide a complete protein matrix that supports muscle repair and recovery, particularly post-training.

Other Ingredients

There are also a few additional ingredients, which are basically what you would call fillers. These include things like dicalcium phoshphate, stearic acid, magnesium stearate, silicon dioxide, pharmaceutical glaze (shellac, povidone),  and soy.

Summary of Effects

PGH-1000 doesn’t rely on hormones or peptides – instead, it uses amino acids and a pituitary extract to support the conditions necessary for natural GH release. While individual ingredient effects vary, the combination may aid:

• Sleep recovery
• Workout endurance
• Post-exercise repair
• Hormonal balance

Potential Side Effects of Taking PGH-1000

When taking illegal HGH injections, especially in excess, there are a number of unpleasant and dangerous side-effects that can occur, including:

• Nerve, joint, and muscle pain
• The growth of cancerous tumors
• Swelling
• Numbing and tingling of the skin
• Liver damage
• Breast growth in men (gynecomastia)

Some of the most concerning side effects relate to the growth of cancers, hands, feet, and facial features as well as enlarged breasts in males. It does make sense that too much growth hormone would cause not only growth in muscles and bone but also in things you don’t necessarily want to grow.

In contrast, Anabolic Research products cause little or no side effects. Unlike synthetic GH that’s injected externally, PGH-1000 contains a blend of amino acids and other natural ingredients designed to increase IGF-1 production in the body.

For this reason, PGH-1000 can be used by most users with little to no side effects when taken as directed. However, some users may experience minor side effects which can include:

• Elevated Body Temperature: Some ingredients may slightly boost metabolism and cause a mild increase in body temperature. This should normalize shortly after finishing the 30-day cycle.
• Increased Heart Rate: Ingredients that elevate metabolism may also lead to a minor uptick in heart rate. This side effect is usually temporary.
• Sweating: Linked to the potential for mild body temperature elevation and increased heart rate. Typically goes away once the body adjusts.
• Restlessness: A small subset of users report feeling more energized and restless when taking PGH-1000, especially later in the day if taken too close to bedtime.
• Higher Energy Levels: Ingredients like amino acids are known to boost energy, which could make some feel overly energetic or restless. Usually resolves after the first week of use.
• Shakiness: Very rare, but some users are extra sensitive to stimulatory ingredients like amino acids and may experience shakes or jitters with PGH-1000.

These side effects are uncommon, but possible. Any notable incidents of side effects may indicate a need to stop or discontinue use. If you take prescription drugs, suffer from a medical condition, have low or high blood pressure, or a gastric ulcer, you would definitely want to consult a physician or medical professional before use.

Who is PGH-1000 For?

PGH-1000 is designed for adult athletes and bodybuilders over the age of 18 who want to enhance performance, improve body composition, speed recovery, and support muscle growth through increased IGF-1 production.

Specifically, PGH-1000 can benefit:

• Weightlifters: The strength and muscle-building support of PGH-1000 makes it an excellent pre-workout choice for powerlifters, bodybuilders, CrossFit athletes, and other weightlifters looking to boost power output, smash PRs, and progress faster. The recovery benefits are also useful for supporting intense training demands.
• Endurance Athletes: By optimizing energy production pathways and physical output, PGH-1000 can help endurance athletes like cyclists, runners, swimmers, and triathletes train longer and harder while also quickening post-exercise recovery.
• Dieters: For those cutting calories to get leaner, PGH-1000 offers metabolic, energy, and body composition support to help retain calorie-burning muscle mass when running a deficit, leading to better fat loss.
• Anti-Aging Seekers: The range of holistic benefits offered by elevated IGF-1 levels may appeal to middle-aged adults interested in preserving fitness, strength, mental sharpness, libido, skin quality, and vitality as part of an anti-aging regimen.

However, PGH-1000 is quite potent, so oversight from a medical professional is recommended for beginners, first-time supplement users, and anyone with pre-existing health conditions prior to starting supplementation. Proper precautions should be taken.

PGH-1000 Recommended Use

PGH-1000 comes in a bottle containing 60 tablets which is designed to be a 30-day cycle. The recommended dosage is to take 1 tablet twice per day. Tablets should be taken with 8 ounces of water, once in the morning and once in the evening is ideal.

The ingredients in PGH-1000 are intended to stimulate the body’s natural IGF-1 production over time when taken consistently. To experience the full range of benefits, it is important to take PGH-1000 according to directions, at the suggested dosage, for the entire 30-day cycle.

Exceeding the recommended dose of 1 tablet twice per day is not advised. Those under 18 years old, pregnant or nursing women, or individuals with certain medical conditions should consult a doctor before using PGH-1000. Discontinue use immediately if adverse reactions occur.

Stacking Options

For enhanced results, PGH-1000 can be stacked or paired with other top-selling legal steroids from Anabolic Research.

One recommended stack is with ThermoClen, a thermogenic fat burner designed to ramp up metabolism, increase calorie burn, and accelerate fat loss. This non-hormonal supplement contains stimulating ingredients to support energy and weight loss.

Another suggested stacking option is TEST-600x, an advanced testosterone-boosting complex. It includes key vitamins, minerals, and herbal extracts to naturally optimize testosterone. Higher T-levels promote faster muscle growth, better strength gains, and enhanced endurance.

For those seeking massive muscle growth, Anabolic Research recommends stacking PGH-1000 with D-DRODIOL 25, an alternative supplement that mimics some of the bulking and mass-building effects of the anabolic steroid Dianabol. D-DRODIOL 25 helps bodybuilders rapidly pack on lean muscle.

Finally, stacking PGH-1000 with DECA 200 can enhance anabolic effects. DECA 200 contains compounds that copy the properties of the popular steroid Deca-Durabolin to accelerate muscle gains, soothe joint discomfort, and shorten recovery times.

Carefully review each product before stacking PGH-1000 to understand possible side effects. Beginning with lower doses is wise to assess tolerance. Those under 18 or with medical issues should avoid stacking without a doctor’s guidance.

Manufacturer’s Video

Review of My Results Using PGH-1000

As an avid gym-goer and former college athlete now in my late 30s, I’ve been looking for ways to gain muscle and get more from my workouts. I’ve hit a plateau with my usual whey protein and pre-workout combination, so I decided to give PGH-1000 a try after researching the impressive benefits of higher IGF-1 levels.

I stacked PGH-1000 with my usual pre-workout and whey to enhance absorption. Within the first couple weeks lifting weights, I was pumped to notice a significant uptick in strength—I added over 30 pounds to my bench press max seemingly overnight! I broke PRs on most compound lifts those first few workouts as strength gains kicked in fast.

By week 3, I clearly had more muscle fullness and definition even while keeping calories moderate. My endurance and capacity to handle volume improved noticeably too. Within a month using PGH-1000 consistently alongside weight training, I packed on a solid 8 pounds—which at my age is significant and would normally take almost double the time naturally.

Recovery has also been phenomenal; I bounce back faster between intense sessions. No more soreness lingering for 3-4 days after heavy squats or deadlifts! Plus, I feel much more energetic, focused, and mentally sharp thanks to the cognitive effects of boosted IGF-1.

For me, PGH-1000 has been a game changer. I’m stronger, bigger, leaner, and training better just one month after starting this powerful muscle-building stack. I plan to use it again pre-competition to put on dense, quality mass with accelerated fat loss—the perfect bodybuilding combo!

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PGH-1000 Review: Pros and Cons

Anabolic Research has created tablets that promote PGH-1000 production to improve overall health, brain function, muscle growth, stamina, tighter skin, and fat loss. Aside from all the benefits of taking PGH-1000, it’s also a major plus that there are no injections necessary when using this product, and no harmful side-effects.

Just take two tablets per day, and you’re good to go. Plus, they offer a discount — and who doesn’t love a discount? But while the discount is great, it still may seem rather expensive for a supplement, but that depends on your priorities and what you’re hoping to achieve by increasing your levels of PGH-1000.

Another potentially significant downside to this supplement is that it could cause you to test positive for a drug screening:

Comparing PGH-1000 to Other GH Releasers

Product	Usage	Cycle Duration	Key Ingredients	Offers/Discounts
	1 tablet twice per day	30-day cycle	L-Glutamic Acid, L-Proline, L-Isoleucine, L-Threonine, L-Alanine, L-Serine, L-Phenylalanine, L-Arginine, L-Tyrosine, L-Histidine, L-Glycine, L-Methionine, L-Cystine, L-Leuicine, Pituitary Substance, HCIL-Valine, Soy Protein.	Buy 2 get 1 free, free shipping to the US, 60-day money-back guarantee
	2 capsules once per day	2-3 months on, 2 weeks off	Maca root, hawthorne berry extract, mucuna puriens extract, l-arginine	Buy 2 get 1 free, free shipping over $100, 60-day money-back guarantee
	2 sprays in the morning, 4 at bedtime	No cycle specified	Alpha gpc, gaba, glycine, l-arginine, l-dopa bean extract, l-glutamine, l-isoleucine, l-tyrosine, l-valine, moomiyo extract, l-lysine, ornithine alpha ketoglutarate	Buy 2 get 1 free, 90-day money-back guarantee

Bottom Line

If you’re looking for a safe, legal, non-prescription alternative to HGH that supports your body’s natural growth hormone production, PGH-1000 is a solid contender. Its blend of amino acids – including BCAAs, L-Arginine, and Tyrosine – makes it especially useful for muscle recovery, endurance, and overall athletic performance.

And unlike many “GH boosters” that rely on gimmicky ingredients or underdosed blends, PGH-1000 takes a more nutritionally grounded approach, using well-established amino acids and a pituitary extract to support the hormonal environment required for growth and repair. While the inclusion of pituitary substance is not backed by strong clinical evidence, the core formula aligns with common practices in recovery and hormone support stacks.

I personally saw undeniable gains while using PGH-1ooo, and although growth hormone supplementation is a controversial subject, it can have a range of significant benefits as well as help to build muscle mass.

At the same time, PGH-1000 isn’t some kind of miracle pill. It won’t replace disciplined training, clean nutrition, or quality sleep. And its results can vary depending on your age, lifestyle, and genetics.

Overall, PGH-1000 is a smart, ingredient-driven supplement for those who understand what natural hormone support can – and can’t – do. If you’re already consistent in the gym and want to enhance recovery and performance, it’s a product that’s definitely worth trying.

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See Also: The Top 5 Best HGH Supplements of 2026

Frequently Asked Questions (FAQ) About PGH-1000

Q: What is PGH-1000?
A: PGH-1000 is a legal supplement from Anabolic Research designed to support natural growth hormone (GH) and IGF-1 production. It uses a proprietary blend of amino acids and pituitary extract to promote muscle growth, fat metabolism, recovery, and overall performance.

Q: How does PGH-1000 work?
A: PGH-1000 helps the body naturally boost IGF-1, which in turn supports human growth hormone activity. This process enhances protein synthesis, recovery, fat burning, brain function, bone density, and even skin health.

Q: What are the main benefits of taking PGH-1000?
A: Reported benefits include increased lean muscle mass, fat loss, faster recovery, higher energy levels, improved focus, better sexual health, and anti-aging effects.

Q: What ingredients are in PGH-1000?
A: Key ingredients include L-Arginine, BCAAs (L-Leucine, L-Isoleucine, L-Valine), L-Tyrosine, L-Phenylalanine, L-Glutamic Acid, Soy Protein, and Pituitary Substance. These work together to promote muscle repair, hormonal balance, endurance, and recovery.

Q: Are there any side effects?
A: Most users tolerate PGH-1000 well, but some may experience mild side effects such as elevated body temperature, restlessness, increased heart rate, sweating, or shakiness. These usually subside with continued use. Always consult a doctor before starting, especially if you have health conditions or take medications.

Q: Who should use PGH-1000?
A: PGH-1000 is intended for adults over 18—particularly bodybuilders, athletes, dieters, and individuals interested in anti-aging benefits. It is not recommended for minors, pregnant or nursing women, or those with certain medical conditions without medical supervision.

Q: How do I take PGH-1000?
A: The standard dosage is 1 tablet twice daily (morning and evening) with water, for a 30-day cycle. Exceeding this dose is not advised.

Q: Can PGH-1000 be stacked with other supplements?
A: Yes. Popular stacking options include ThermoClen (fat burner), TEST-600x (testosterone booster), D-DRODIOL 25 (muscle growth), and DECA 200 (joint and recovery support). Always assess tolerance and check with a healthcare provider before stacking.

Q: Will PGH-1000 cause me to fail a drug test?
A: Possibly. Professional athletes may test positive for performance-enhancing substances while using PGH-1000, so it’s important to check the regulations of your sport before use.

Q: Is PGH-1000 safe?
A: When used as directed, PGH-1000 is considered a safe and legal alternative to synthetic HGH injections. However, results vary by individual and it should not replace proper diet, training, and rest.

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Jim Marshall

Jim is the founder of Andro HQ and a self-taught supplement reviewer with over 12 years of personal testing experience. He has evaluated more than 150 bodybuilding products and specializes in identifying effective, science-backed alternatives to banned substances. His insights are grounded in real-world use, documented trials, and continuous experimentation in the gym. While not a licensed health professional, Jim aims to help readers navigate the often-confusing supplement market through honest, evidence-informed reviews. More about this author…